The Kolk lab
Developmental Neurobiology

Key papers:

  1. Coenen-van der Spek, J., Relator, R., Kerkhof, J., McConkey, H., Levy, MA, Tedder, ML, Louie, RJ, Fletcher, RS, Moore, HW, Childers, A., Farrelly, ER, Champaigne, NL, Lyons, MJ, Everman, DB, Rogers, RC, Skinner, SA, Renck, A., Matalon, DR, Dills, SK, Monteleone, B., Demirdas, S., Dingemans, AJM, Donker Kaat, L., Kolk, SM, Pfundt, R., Rump, P., Sadikovic, B., Kleefstra, T., & Butler, KM (2022, 11-18-2022). DNA methylation episignature for Witteveen-Kolk syndrome due to SIN3A haploinsufficiency. Genetics in Medicine. https://doi.org/https://doi.org/10.1016/j.gim.2022.10.004
  2. Witteveen, JS, Loopstok, SR, Ballesteros, LL, Boonstra, A., van Bakel, NHM, van Boekel, WHP, Martens, GJM, Visser, JE, & Kolk, SM (2022, Jun 4). HGprt deficiency disrupts dopaminergic circuit development in a genetic mouse model of Lesch-Nyhan disease. Cell Mol Life Sci, 79(6), 341. https://doi.org/10.1007/s00018-022-04326-x
  3. Kolk, S. M., & Rakic, P. (2022, 2022/01/01). Development of prefrontal cortex. Neuropsychopharmacology, 47(1), 41-57. https://doi.org/10.1038/s41386-021-01137-9
  4. Homberg, JR, Adan, RAH, Alenina, N., Asiminas, A., Bader, M., Beckers, T., Begg, DP, Blokland, A., Burger, ME, van Dijk, G., Eisel, ULM , Elgersma, Y., Englitz, B., Fernandez-Ruiz, A., Fitzsimons, CP, van Dam, AM, Gass, P., Grandjean, J., Havekes, R., Henckens, M., Herden, C ., Hut, RA, Jarrett, W., Jeffrey, K., Jezova, D., Kalsbeek, A., Kamermans, M., Kas, MJ, Kasri, NN, Kiliaan, AJ, Kolk, SM, Korosi, A., Korte, SM, Kozicz, T., Kushner, SA, Leech, K., Lesch, KP, Lesscher, H., Lucassen, PJ, Luthi, A., Ma, L., Mallien, AS , Meerlo, P., Mejias, JF, Meye, FJ, Mitchell, AS, Mul, JD, Olcese, U., González, AO, Olivier, JDA, Pasqualetti, M., Pennartz, CMA, Popik, P., Prickaerts , J., de la Prida, LM, Ribeiro, S., Roozendaal, B., Rossato, JI, Salari, AA, Schoemaker, RG, Smit, AB, Vanderschuren, L., Takeuchi, T., van der Veen, R., Smidt, MP, Vyazovskiy, VV, Wiesmann, M., Wierenga, CJ, Williams, B., Willuhn, I., Wöhr, M., Wolvekamp, ​​​​M., van der Zee, EA, & Genzel , L (2021, Aug 4). The continued need for animals to advance brain research. Neuron, 109(15), 2374-2379. https://doi.org/10.1016/j.neuron.2021.07.015
  5. Jansen, EJR, van Bakel, NHM, Benedict, B., Olde Loohuis, NFM, Hafmans, TGM, Chim, SM, Xu, J., Kolk, SM, & Martens, GJM (2021, Jul). Novel vertebrate- and brain-specific driver of neuronal outgrowth. Prog Neurobiol, 202, 102069. https://doi.org/10.1016/j.pneurobio.2021.102069
  6. Hanswijk, SI, Spoelder, M., Shan, L., Verheij, MMM, Muilwijk, OG, Li, W., Liu, C., Kolk, SM, & Homberg, JR (2020). Gestational Factors throughout Fetal Neurodevelopment: The Serotonin Link. International Journal of Molecular Sciences, 21(16), 5850. https://www.mdpi.com/1422-0067/21/16/5850
  7. Garcia, LP, Van de Wijer, L., Hanswijk, SI, Rando, J., Witteveen, JS, Middelman, A., Ter Heine, R., de Mast, Q., Martens, GJM, van der Ven, A., Schellekens, AFA, Homberg, JR, & Kolk, SM (2020, Aug). Perinatal exposure of rats to the HIV drug efavirenz affects medial prefrontal cortex cytoarchitecture. Biochem Pharmacol, 178, 114050. https://doi.org/10.1016/j.bcp.2020.114050
  8. van de Wijer, L., Garcia, LP, Hanswijk, SI, Rando, J., Middelman, A., ter Heine, R., Mast, Q. d., Martens, GJM, van der Ven, AJAM, Kolk, SM, Schellekens, AFA, & Homberg, JR (2019, 2019-02-11). Neurodevelopmental and behavioral consequences of perinatal exposure to the HIV drug efavirenz in a rodent model. Translational Psychiatry, 9(1), 84. https://doi.org/10.1038/s41398-019-0420-y
  9. Garcia, LP, Witteveen, JS, Middelman, A., van Hulten, JA, Martens, GJM, Homberg, JR, & Kolk, SM (2019, Feb). Perturbed Developmental Serotonin Signaling Affects Prefrontal Catecholaminergic Innervation and Cortical Integrity. Mol Neurobiol, 56(2), 1405-1420. https://doi.org/10.1007/s12035-018-1105-x
  10. Kos, A., de Mooij-Malsen, AJ, van Bokhoven, H., Kaplan, BB, Martens, GJ, Kolk, SM, & Aschrafi, A. (2017, Jul 3). MicroRNA-338 modulates cortical neuronal placement and polarity. RNA Biol, 14(7), 905-913. https://doi.org/10.1080/15476286.2017.1325067
  11. Kroeze, Y., Oti, M., van Beusekom, E., Cooijmans, RHM, van Bokhoven, H., Kolk, SM, Homberg, JR, & Zhou, H. (2018, Mar 1). Transcriptome Analysis Identifies Multifaceted Regulatory Mechanisms Dictating a Genetic Switch from Neuronal Network Establishment to Maintenance During Postnatal Prefrontal Cortex Development. Cerebral Cortex, 28(3), 833-851. https://doi.org/10.1093/cercor/bhw407
  12. Witteveen, JS, Willemsen, MH, Dombroski, TCD, van Bakel, NHM, Nillesen, WM, van Hulten, JA, Jansen, EJR, Verkaik, D., Veenstra-Knol, HE, van Ravenswaaij-Arts, CMA, Wassink- Ruiter, JSK, Vincent, M., David, A., Le Caignec, C., Schieving, J., Gilissen, C., Foulds, N., Rump, P., Strom, T., Cremer, K., Zink, AM, Engels, H., de Munnik, SA, Visser, JE, Brunner, HG, Martens, GJM, Pfundt, R., Kleefstra, T., & Kolk, SM (2016, 7/11/2016). Haploinsufficiency of MeCP2-interacting transcriptional co-repressor SIN3A causes mild intellectual disability by affecting the development of cortical integrity. Nature Genetics, 48(8), 877-887. https://doi.org/10.1038/ng.3619
  13. Kos, A., Klein-Gunnewiek, T., Meinhardt, J., Loohuis, N., van Bokhoven, H., Kaplan, BB, Martens, GJ, Kolk, SM, & Aschrafi, A. (2017, Jul) . MicroRNA-338 Attenuates Cortical Neuronal Outgrowth by Modulating the Expression of Axon Guidance Genes. Mol Neurobiol, 54(5), 3439-3452. https://doi.org/10.1007/s12035-016-9925-z
  14. Schubert, D., Martens, GJM, & Kolk, SM (2015, 2015-07//). Molecular underpinnings of prefrontal cortex development in rodents provide insights into the etiology of neurodevelopmental disorders. Molecular Psychiatry, 20(7), 795-809. https://doi.org/10.1038/mp.2014.147
  15. Schmidt, ERE, Brignani, S., Adolfs, Y., Lemstra, S., Demmers, J., Vidaki, M., Donahoo, AS, Lilleväli, K., Vasar, E., Richards, LJ, Karagogeos, D ., Kolk, SM, & Pasterkamp, ​​RJ (2014, Jul 16). Subdomain-mediated axon-axon signaling and chemoattraction cooperate to regulate afferent innervation of the lateral habenula. Neuron, 83(2), 372-387. https://doi.org/10.1016/j.neuron.2014.05.036
  16. Homberg, JR, Kolk, SM, & Schubert, D. (2013). Editorial perspective of the Research Topic "Deciphering serotonin's role in neurodevelopment". Frontiers in Cellular Neuroscience, 7, 212. https://doi.org/10.3389/fncel.2013.00212
  17. Witteveen, JS, Middelman, A., van Hulten, JA, Martens, GJM, Homberg, JR, & Kolk, SM (2013, 10/4/2013). Lack of serotonin reuptake during brain development alters rostral raphe-prefrontal network formation. Frontiers in Cellular Neuroscience, 7, 143. https://doi.org/10.3389/fncel.2013.00143
  18. Kolk, SM, de Mooij-Malsen, AJ, & Martens, GJ (2011). Spatiotemporal Molecular Approach of In Utero Electroporation to Functionally Decipher Endophenotypes in Neurodevelopmental Disorders. Front Mol Neurosci, 4, 37. https://doi.org/10.3389/fnmol.2011.00037
  19. Kolk, SM, Gunput, RA, Tran, TS, van den Heuvel, DM, Prasad, AA, Hellemons, AJ, Adolfs, Y., Ginty, DD, Kolodkin, AL, Burbach, JP, Smidt, MP, & Pasterkamp, RJ (2009, Oct 7). Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting. J Neurosci, 29(40), 12542-12557. https://doi.org/10.1523/jneurosci.2521-09.2009
  20. North, HA, Zhao, X., Kolk, SM, Clifford, MA, Ziskind, DM, & Donoghue, MJ (2009, Jul). Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling. Development, 136(14), 2467-2476. https://doi.org/10.1242/dev.034405